18 Juillet – Thesis defense - Louis Cassany

14 h30 Amphi Jean-Paul Dom - laboratory IMS / building A31 (University of Bordeaux - Talence campus)

Glycemia modelisation and regulation in type-1 diabetes.

Recent advancements in CGM sensors (Continuous Glucose Monitoring) and insulin pumps considerably improved the treatment of diabetes. However, CGM sensors can only measure the blood glucose level, limiting the insulin therapy algorithms. The IMS laboratory (Integration: from Material to Systems), the CBMN laboratory (Chemistry, Biology of Membranes and Nano-objects) and the CHU (University Hospital Center) gather specialists in diabetes, pancreatic islet biology, microelectronics and automatic control in order to develop new solutions for glycemic measurement and regulation for patients with diabetes. The work of this thesis falls within this context. The goal is to use the tools of the robust control theory in order to develop new insulinotherapy algorithms that can adapt to the physiological variability of the patient (age, weight...). These algorithms will be evaluated in the UVA/Padova simulator, currently the only simulator approved by the FDA (Food and Drug Administration) for in silico pre-clinical tests.

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